What is CJC-1295 with DAC?
CJC-1295 with DAC (Drug Affinity Complex) is a synthetic analog of growth hormone–releasing hormone (GHRH)
engineered to extend half-life and activity in the body. The addition of the DAC molecule allows the peptide to bind to serum albumin,
greatly prolonging its duration of action compared to non-DAC versions.
CJC-1295 with DAC has been studied for its ability to stimulate growth hormone (GH) and IGF-1 secretion,
supporting tissue growth, repair, and metabolic regulation.
CJC-1295 with DAC Structure
| Peptide Name | CJC-1295 with DAC |
|---|---|
| Synonyms | Modified GRF (1-29) DAC |
| Sequence | Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-DAC |
| Molecular Formula | Varies with DAC conjugation |
| Molecular Weight | ~3647.1 g/mol (base peptide, before DAC attachment) |
CJC-1295 with DAC Research
1. Extended Half-Life
Compared to CJC-1295 without DAC, the DAC version significantly increases peptide stability.
Its half-life extends to about 5–8 days, allowing weekly or biweekly dosing in research settings.
2. Growth Hormone & IGF-1 Stimulation
Studies show CJC-1295 with DAC enhances pulsatile GH release and increases serum IGF-1 levels,
which are associated with tissue repair, muscle growth, and fat metabolism.
3. Potential Applications
Research suggests benefits in muscle recovery, anti-aging studies, improved body composition,
and potential neuroprotective effects, though these areas remain under active investigation.
Future CJC-1295 with DAC Research
Future studies are expected to evaluate the long-term safety of extended GH stimulation,
the role of CJC-1295 DAC in age-related decline, and its combination with other secretagogues
such as Ipamorelin to optimize GH release profiles.
CJC-1295 with DAC Resources
- Teichman SL, et al. – “CJC-1295, a long-acting growth hormone-releasing hormone analog,
increases growth hormone and IGF-I in healthy adults.” J Clin Endocrinol Metab, 2006. - Research on GHRH analog stability and DAC conjugation methods.
- Studies comparing CJC-1295 with and without DAC for half-life and GH release profiles.

Reviews
There are no reviews yet.