What is Ipamorelin?
Ipamorelin is a selective growth hormone secretagogue and ghrelin receptor agonist.
Unlike earlier secretagogues, Ipamorelin is highly specific for stimulating growth hormone (GH) release
without significantly affecting cortisol, prolactin, or other hormones.
It has been researched for its ability to mimic natural GH pulses, support lean muscle growth,
accelerate recovery, and promote fat metabolism.
Ipamorelin Structure
| Peptide Name | Ipamorelin |
|---|---|
| Synonyms | NNC 26-0161 |
| Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH2 |
| Molecular Formula | C38H49N9O5 |
| Molecular Weight | 711.9 g/mol |
Ipamorelin Research
1. Growth Hormone Release
Ipamorelin selectively binds to ghrelin receptors, stimulating pulsatile GH secretion from the pituitary.
Unlike older secretagogues such as GHRP-6, it does not cause sharp increases in cortisol or prolactin,
making it a cleaner GH secretagogue in research studies.
2. Muscle Growth & Recovery
Preclinical studies suggest Ipamorelin may support lean muscle growth and enhance recovery
by increasing circulating GH and subsequent IGF-1 activity,
which promotes protein synthesis and tissue repair.
3. Fat Metabolism
GH release triggered by Ipamorelin has been linked to enhanced lipolysis (fat breakdown)
and improved body composition in research models.
4. Anti-Aging & Regenerative Studies
Because GH levels naturally decline with age, Ipamorelin has been investigated
for its role in restoring more youthful GH patterns, supporting metabolism, energy, and tissue regeneration.
Future Ipamorelin Research
Future studies may explore Ipamorelin in combination with other secretagogues
such as CJC-1295 to enhance GH pulsatility. Research also continues into its potential role
in muscle-wasting conditions, healthy aging, and metabolic disease management.
Ipamorelin Resources
- Bowers CY, et al. – “Ipamorelin: a selective growth hormone secretagogue.” Peptides, 1998.
- Clinical research on ghrelin receptor agonists for GH release and metabolic regulation.
- Studies on GH secretagogues in muscle recovery, body composition, and aging models.

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