MOTS-C – 10 mg

MOTS-c (Mitochondrial ORF of the Twelve S-c) is a mitochondrial-derived peptide (MDP)
encoded within the mitochondrial 12S rRNA gene.
It plays a unique role in regulating cellular metabolism, energy homeostasis, and stress adaptation.
MOTS-c has been researched for its potential to enhance insulin sensitivity, support weight management,
and improve exercise capacity by influencing nuclear gene expression related to metabolism.

1. MOTS-c and Metabolic Regulation

Studies show that MOTS-c enhances glucose uptake in skeletal muscle and improves insulin sensitivity.
It activates AMPK pathways, increasing energy expenditure and promoting fat oxidation.

2. MOTS-c and Weight Management

Preclinical models suggest MOTS-c may reduce diet-induced obesity by shifting metabolism toward increased fat burning
and reduced fat storage, without significantly affecting appetite.

3. MOTS-c and Exercise Performance

MOTS-c has been reported to improve exercise tolerance and endurance by supporting mitochondrial function
and regulating genes associated with energy metabolism and muscle adaptation.

4. MOTS-c and Aging Research

Because mitochondrial dysfunction is linked to aging, MOTS-c is being studied for its role in longevity,
cellular repair, and protection against age-related metabolic decline.

Future research aims to clarify MOTS-c’s applications in obesity, diabetes, cardiovascular health,
and age-associated diseases. Additional studies may explore its ability to improve mitochondrial resilience,
protect against neurodegeneration, and extend healthy lifespan.