What is Sermorelin?
Sermorelin (GRF 1-29) is a synthetic peptide analog of the first 29 amino acids
of growth hormone–releasing hormone (GHRH).
It was developed to stimulate the pituitary gland’s natural release of growth hormone (GH)
rather than providing exogenous GH directly.
This makes Sermorelin a research candidate in the areas of growth hormone deficiency,
anti-aging, and metabolic regulation.
Sermorelin Structure
| Peptide Name | Sermorelin |
|---|---|
| Synonyms | GRF 1-29, GHRH (1-29) NH2 |
| Sequence | Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2 |
| Molecular Formula | C149H246N44O42 |
| Molecular Weight | 3357.9 g/mol |
Sermorelin Research
1. Sermorelin and Growth Hormone Deficiency
Research indicates that Sermorelin stimulates endogenous GH release in subjects with GH deficiency.
Unlike direct GH administration, it activates the natural feedback loop, reducing the risk of overdose or suppression of GH secretion.
2. Sermorelin and Body Composition
Studies suggest potential improvements in lean body mass, reduction in fat mass,
and support for muscle recovery, making Sermorelin a focus of metabolic and performance-related research.
3. Sermorelin and Anti-Aging Research
Because GH production declines with age, Sermorelin has been investigated for its potential to restore
more youthful GH levels, possibly improving energy, sleep quality, skin elasticity, and bone density in aging models.
Future Sermorelin Research
Future studies may clarify Sermorelin’s role in long-term GH restoration,
cognitive function, cardiovascular health, and healthy aging.
Its safety profile and natural stimulation mechanism make it a promising candidate
compared to synthetic GH replacement therapies.
Sermorelin Resources
- Walker RF, et al. – “Stimulation of Growth Hormone Secretion in Humans by Sermorelin.” J Clin Endocrinol Metab, 1990.
- Clinical research on GRF 1-29 analogs in GH deficiency and aging.
- Reviews on endogenous GH stimulation versus GH replacement therapies.

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