What is Snap-8?
Snap-8 (Acetyl Octapeptide-3) is a synthetic peptide
developed as an extended version of Argireline (Acetyl Hexapeptide-8).
It is commonly referred to as a “Botox-like” peptide due to its ability
to reduce the depth of facial expression wrinkles caused by muscle contractions.
Snap-8 is widely studied in cosmetic and dermatological research as a safer,
non-invasive alternative to botulinum toxin for anti-aging applications.
Snap-8 Structure
| Peptide Name | Snap-8 |
|---|---|
| Synonyms | Acetyl Octapeptide-3, Argireline Amplified |
| Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 |
| Molecular Formula | C39H60N12O14 |
| Molecular Weight | 868.97 g/mol |
Snap-8 Research
1. Anti-Wrinkle Effects
Snap-8 has been shown in cosmetic research to reduce the depth of wrinkles,
especially those caused by facial expressions such as crow’s feet and forehead lines.
It works by interfering with the SNARE complex, similar to Botox,
but without paralysis of muscles.
2. Comparison to Argireline
As an extension of Argireline, Snap-8 demonstrates stronger activity and longer-lasting results
in reducing wrinkle formation, making it a next-generation cosmetic peptide.
3. Safety & Non-Invasive Profile
Unlike botulinum toxin injections, Snap-8 is applied topically in skincare formulations,
offering a safe and non-invasive approach to wrinkle reduction.
4. Synergy with Other Cosmetic Peptides
Snap-8 is often studied in combination with peptides like Matrixyl and GHK-Cu
for enhanced anti-aging and skin rejuvenation effects.
Future Snap-8 Research
Future studies are expected to explore Snap-8’s role in comprehensive anti-aging formulations,
its potential for skin tightening, and long-term safety in cosmetic dermatology.
Ongoing research also examines synergistic effects with antioxidants and growth factor peptides
in advanced skincare.
Snap-8 Resources
- Blanes-Mira C, et al. – “A synthetic hexapeptide (Argireline) and its analogues in cosmetic dermatology.” Int J Cosmet Sci, 2002.
- Clinical studies comparing Argireline and Snap-8 in wrinkle reduction efficacy.
- Research on cosmetic peptides in non-invasive anti-aging skincare.

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