What is TB-500?
TB-500 is the synthetic version of a naturally occurring peptide fragment
of Thymosin Beta-4 (Tβ4), a protein found in nearly all human and animal cells.
TB-500 is studied for its role in wound healing, tissue regeneration, angiogenesis, and anti-inflammatory processes.
Research suggests it may accelerate recovery from injuries, support cardiovascular health,
and improve cell migration during tissue repair.
TB-500 Structure
| Peptide Name | TB-500 |
|---|---|
| Synonyms | Thymosin Beta-4 fragment |
| Sequence | Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr |
| Molecular Formula | C212H350N56O78S |
| Molecular Weight | ~4963 g/mol |
TB-500 Research
1. Wound Healing & Tissue Repair
TB-500 has been shown in preclinical models to accelerate the repair of injured tissues,
including muscle, tendons, and ligaments. Its ability to regulate cell migration and differentiation
plays a central role in regeneration.
2. Angiogenesis (New Blood Vessel Formation)
Research indicates TB-500 promotes angiogenesis,
improving blood flow to damaged tissues and enhancing recovery in cardiovascular and ischemic models.
3. Anti-Inflammatory Effects
TB-500 exhibits anti-inflammatory properties that may help reduce swelling, oxidative stress,
and fibrotic tissue formation during injury recovery.
4. Neurological & Systemic Benefits
Studies suggest TB-500 may support nerve regeneration and provide systemic healing effects,
broadening its potential applications in regenerative medicine.
Future TB-500 Research
Future research may expand into cardiovascular repair,
chronic injury recovery, neurological regeneration,
and treatment of inflammatory disorders.
Long-term human studies are needed to better define its potential benefits and safety profile.
TB-500 Resources
- Catrina AI, et al. – Studies on Thymosin Beta-4 and wound healing. J Cell Biol, 2003.
- Goldstein AL, et al. – “Thymosin Beta-4 and tissue regeneration research.”
- Preclinical findings on angiogenesis and anti-inflammatory properties of TB-500.

Reviews
There are no reviews yet.