What is Tesamorelin / Ipamorelin Blend?
Tesamorelin / Ipamorelin Blend combines the properties of
Tesamorelin, a synthetic analog of growth hormone–releasing hormone (GHRH),
with Ipamorelin, a selective growth hormone secretagogue (ghrelin receptor agonist).
This synergistic blend is researched for its ability to enhance natural growth hormone release,
stimulate IGF-1 production, support lean muscle growth, reduce visceral fat,
and accelerate recovery processes. The dual mechanism offers a more comprehensive approach
compared to using either peptide alone.
Tesamorelin / Ipamorelin Blend Structure
| Blend Name | Tesamorelin / Ipamorelin |
|---|---|
| Components | Tesamorelin (GHRH analog, 44 amino acids) + Ipamorelin (5-amino acid secretagogue) |
| Synonyms | TH9507 + NNC 26-0161 |
| Molecular Formula | Varies (multi-peptide blend) |
| Molecular Weight | Tesamorelin ≈ 5135.9 g/mol; Ipamorelin ≈ 711.9 g/mol |
Tesamorelin / Ipamorelin Blend Research
1. Growth Hormone & IGF-1 Secretion
Tesamorelin stimulates the pituitary via GHRH receptors,
while Ipamorelin targets ghrelin receptors to induce pulsatile GH release.
Together, they provide a synergistic increase in GH and IGF-1 without excessive cortisol or prolactin stimulation.
2. Body Composition & Fat Reduction
Tesamorelin has been FDA-approved for reducing visceral adipose tissue in HIV-associated lipodystrophy,
while Ipamorelin research links it to fat metabolism and lean muscle preservation.
The blend may therefore support improved body composition outcomes in research models.
3. Muscle Growth & Recovery
Both peptides support protein synthesis, tissue regeneration, and recovery from injury.
The combination has been studied in contexts of muscle wasting, injury repair, and performance recovery.
4. Anti-Aging & Regenerative Potential
With GH decline associated with aging, the blend is being investigated for healthy longevity,
improved energy, better sleep, and regenerative support.
Future Tesamorelin / Ipamorelin Blend Research
Future research will likely evaluate the long-term safety of combined GHRH analogs and secretagogues,
their role in age-related decline, and therapeutic potential in metabolic syndrome,
muscle wasting disorders, and regenerative medicine.
Studies may also assess optimized dosing protocols to maximize synergy while minimizing risks.
Tesamorelin / Ipamorelin Blend Resources
- Falutz J, et al. – “Metabolic effects of Tesamorelin in HIV-infected patients with abdominal fat accumulation.” NEJM, 2010.
- Bowers CY, et al. – “Ipamorelin: a selective growth hormone secretagogue.” Peptides, 1998.
- Comparative studies on GHRH analogs and ghrelin mimetics for GH pulsatility and IGF-1 stimulation.

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